Publications

96. “Re2O7-catalyzed reaction of hemiacetals and aldehydes with O-, S-, and C-nucleophiles” Sittiwong, W.; Richardson, M.; Schiaffo, C. E.; Fisher, T. J.; Dussault, P. H.  Beilstein J. Org. Chem. 201391526-32.

95.  “Design and Synthesis of a New Class of Twin-Chain Amphiphiles for Self- Assembled Monolayer-based Electrochemical Biosensor Applications“  Dussault, P. H.; Fisher, T. J.; Cañete, S. J. P.; Lai, R.. Eur. J. Org. Chem.2013, 3263-70.

94. “Synthesis of Alkyl Hydroperoxides via Alkylation of gem-Dihydroperoxides”(Kyasa, S.; Puffer, B. W.; Dussault, P. H. J. Org. Chem. 201378, 3452–3456.

93. ”Tandem application of C-C bond-forming reactions with reductive ozonolysis”  Willand-Charnley, R.; Dussault, P. H., J. Org. Chem, 201378, 42-47.

92. "In vitro and in vivo activity of 3-alkoxy-1,2-dioxolanes against Schistosoma mansoni" Ingram, K.; Schiaffo, C.; Sittiwong, W.; Benner, E.; Dussault, P. H.; Keiser, J.* Journal of Antimicrobial Chemotherapy, 2012, 67, 1979-86.

91. "Pyridine as an organocatalyst for the reductive ozonolysis of alkenes" R. Willand-Charnley, T. Fisher, B. Johnson, and P. H. Dussault Org. Lett. 2012, 14, 2242.

90. "Regioselective Synthesis of tetralkynylarenes via Consecutive Dual Sonogashira Couplings of the bistriflate of 1,2-Dihydroxy-4,5-diodobenzene", Fisher T.; Dussault, P. H. Eur. J. Org. Chem. 2012, 2831-4.  

89. "Generation of singlet oxygen from fragmentation of monoactivated 1,1-dihydroperoxides" Hang, J.; Ghorai, P.; Finkenstaedt-Quinn, S.; Findik, I; Sliz, E.; Kuwata, K. T, Dussault, P. H.*, J. Org. Chem, 2012, 77(3), 1233–1243; Feature article.  

88. "A Mild One-pot Conversion of Alkenes to Amines through Tandem Ozonolysis and Reductive Amination" by Kyasa, S-K.; Fisher, T. J.; Dussault, P. H. Synthesis, 2011, 3475-3481.

87. "Phytosterol stearate esters elicit similar responses on plasma lipids and cholesterol absorption but different responses on fecal neutral sterol excretion and hepatic free cholesterol in male Syrian hamsters"  Ash, M. M.; Hang, J.; Dussault, P. H. Carr. T. P. Nutr. Res. 2011, 31(7), 537-543.  

86. "N5-phosphonoacetyl-L-ornithine (PALO): a convenient synthesis and investigation of influence on regulation of amino acid biosynthetic genes in Saccharomyces cerevisiae."  Johnson, B.; Steadman, R.; Fager, K.; Bunker, J.; Atkin, A.*, Dussault, P. H.*  Biorg. Med. Chem. Lett. 201121, 2351-3.

85.  "3-Alkoxy-1,2-Dioxolanes: Synthesis and Evaluation as Potential Antimalarial Agents" Schiaffo, C. E.; Rottman, M.; Wittlin, S.; Dussault, P. H.*   ACS Med. Chem. Lett.  20112, 316-319. DOI: 10.1021/ml100308d

84.
“Reversible collapse of the Langmuir films of a series of triphenylsilyl ether-terminated amphiphiles” Christine A. DeVries, James J. Haycraft , Qiang Han, Farhana Noor-e-Ain, Joseph Raible, Patrick H. Dussault, and Craig J. Eckhardt, Thin Solid Films 2011, 519, 2430-2437.

83. “Biosynthesis of HSAF, a Tetramic Acid-containing Macrolactam from Lysobacter enzymogenes L. Lou, G. Qian, Y. Xie, J. Hang, H. Chen, K. Zaleta-Rivera, Y. Li, Y. Shen, P. H Dussault, F. Liu and L. Du*, J. Am. Chem. Soc. 2011, 133, 643-5.

82. “Tandem silylation/hydrosilylation of alkenols:diastereoselective synthesis of 1,4- and 1,5-diols”  Shchepin, R.; Xu, C.; Dussault, P. H.* J. Org. Chem. 2010, 12, 4772-4775.

81. “Efficient synthesis and conformational investigations of cis-pentacenediols”  Jiang, J.; Schiaffo, C. E.; Schwartz, C. P.; Pei, Y.; Dumais J. J.; Zeng, X. C.; Dussault, P. H.; Tan, L.* Tetrahedron Lett. 2010, 51,  5732-5735.

80. Fragmentation of chloroperoxides; hypochlorite-mediated dehydration of hydroperoxyacetals to esters“ Fisher, T. J.; Dussault, P. H.* Tetrahedron Letters, 2010, 51,  5615-5617.

79. “Phytosterol ester constituents affect micellar cholesterol solubility in model bile.” Brown, A. W.; Hang, J.; Dussault, P. H.; Carr, T. P.* Lipids, 2010, 45, 855–862.   DOI: 10.1007/s11745-010-3456-6

78. “A concise synthesis of beta-sitosterol and other phytosterols” Hang, J.; Dussault, P.* Steroids, 2010, 75, 879–883.

77. “Rhenium (VII) Oxide” P. H. Dussault* and P. Ghorai in Encylopedia of Reagents for Organic Synthesis [Online] (e-EROS); editor G. Molander.  John Wiley & Sons, 2010 (editor-reviewed)  

76. “Sterol and stanol substrate specificity of pancreatic cholesterol ester lipase” A. W. Brown, J.Hang, P. H.  Dussault, T. Carr,* J.Nutr.  Biochem., 2010, 21, 736-740.

75. “A new peroxide fragmentation: efficient chemical generation of 1O2 in organic media.” Ghorai, P.; Dussault, P. H.* Org. Lett. 2009, 11, 4572–4575

74. “Asymmetric Synthesis of 1,2-dioxanes: Approaches to the Peroxyplakoric Acids” Xu, C.; Schwartz, C.; Raible, J. D.; Dussault, P. H.* Tetrahedron, 2009, 65, 9680-9685.

73. “Spiroadamantyl 1,2,4-Trioxolane, 1,2,4-Trioxane, and 1,2,4-Trioxepane Pairs:  Relationship Between Peroxide Bond Iron (II) Reactivity, Heme Alkylation Efficiency, and Antimalarial Activity”  X. Wang, D. Creek, C. E. Schiaffo, Y. Dong, J. Chollet, C. Scheurer, S. Wittlin, S. A. Charmanb, P. H. Dussault, J. K. Wood, and J. L. Vennerstrom*  Bioorg. Med. Chem. Lett. 2009, 19, 4542-4545.

72. “A broadly applicable synthesis of 1,2,4,5-tetraoxanes” Ghorai, P.; Dussault, P. H.*  Organic Letters, 2009, 11, 213-216.

71. “A mild and efficient Re(VII)–catalyzed synthesis of  1,1-dihydroperoxides”,   Ghorai, P.; Dussault, P. H.* , Org. Lett., 2008  10, 4577–4579.10.1021/ol801859c

70. “Ozonolysis in solvent/water mixtures; direct conversion of alkenes to aldehydes and ketones” Schiaffo, C. E., Dussault, P. H.* J. Org. Chem. 200873, 4688 – 4690. 10.1021/jo800323x

69. “The Synthesis of spiro-Bisperoxyketals” Ghorai, P.; Dussault, P. H.*, Hu, C. Organic Letters, 2008, 10, 2401 – 2404. 10.1021/ol800657m

68. “Influence of heterocyclic farnesol analogs on quorum sensing and pathogenicity in Candida albicans” R. Shchepin, D. H. M. L. P. Navarathna, R. Dumitru, S. Lippold, K. W. Nickerson, and P. H. Dussault*, Bioorganic & Medicinal Chemistry, 2008, 16, 1842-8.

67. “Fused Ring Oxetanes”, P. H. Dussault and Chunping Xu, in Comprehensive Heterocylic Chemistry III, Elsevier, 2008, Chapter 2.06 (Chris Stevens, editor)

66. “Cholesterol-lowering properties of plant sterols esterified with beef tallow fatty acids in hamsters” Guderian D. M. Jr., Rasmussen H. E., Wray C. A., Dussault P. H., Carr T. P.* Nutr.  Res. 2007, 27, 283-288.

65.“Reductive Ozonolysis” via a new fragmentation of carbonyl oxides” Chris Schwartz, Joseph Raible, Kyle Mott,  and P. H. Dussault* Tetrahedron, 2006, 62, 10747-52.

64. Reduction in cholesterol absorption is enhanced by  stearate-enriched plant sterol esters in hamsters” H. E. Rasmussen, D. M. Guderian Jr., C. A. Wray, P. H. Dussault, V. L. Schlegel, and T. P. Carr* J. Nutr. 2006, 136: 2722–2727.

63. “Fragmentation of Carbonyl Oxides by N-oxides:  An Improved Approach to Alkene Ozonolysis” C. Schwartz, J. Raible, K. Mott and P. H. Dussault* Organic Letters, 2006, 8, 3199 -3201. DOI:  10.1021/ol061001k

62. “Asymmetric Synthesis of 1,2-Dioxolane-3-acetic acids:  Structural Elucidation of Plakinic Acid A” P. Dai, T. K. Trullinger, X. Liu, and P. H. Dussault*; J. Org. Chem. 2006, 71, 2283-2292. 10.1021/jo0522254

61. “A Bi-domain Nonribosomal Peptide Synthetase Encoded by FUM14 Catalyzes the Formation of Tricarballylic Esters in the Biosynthesis of Fumonisins” K. Zaleta-Rivera, C. Xu,  F. Yu, R. A. E. Butchko,  R. H. Proctor, M. E. Hidalgo-Lara,  A. Raza,  P. H. Dussault, and L. Du* Biochemistry 2006, 45, 2561-9. 10.1021/bi052085s

60. “Intramolecular Reactions of  Hydroperoxides and Oxetanes:  Stereoselective Synthesis of 1,2-Dioxolanes  and 1,2-Dioxanes” P. Dai and P. H. Dussault,  Org. Lett.; 2005; 7, 4333 – 4335; minor correction Org. Lett., 2009, 11, 1461.

59. “Total Synthesis of Peroxyacarnoates A and D:  Metal-Mediated Couplings as a Convergent Approach to Polyunsaturated Peroxides”  C. Xu, J. Raible, and P. H. Dussault*  Org. Lett. 2005, 7, 2509-11. DOI: 10.1021/ol050291m

58. Biologically Active Fluorescent Farnesol Analogs”

R. Shchepin, R. Dumitru, M. Lund, K. Nickerson and P. H. Dussault*, Chem. Biol. 2005, 12, 639-641.

57.“Stereoselective Allylation of Chiral Monoperoxyacetals”  A. Ahmed and P. H. Dussault, Tetrahedron 2005,  61,   4657-4670.

56. “1,2,4-Trioxepanes:  Redox Cleavable Protection for Carbonyl Groups”  A. Ahmed and P. H. Dussault*,  Org. Lett. 20046, 3609-3611. 10.1021/ol048484h

55. “Curtius rearrangement and Wolff homologation of functionalized peroxides “,  P. H. Dussault* and C. Xu,  Tetrahedron Lett.  2004,  45,  pp 7455-7457

54. “Magnesium/Methanol:  An Effective Reducing Agent for Peroxides and Ozonides” Peng Dai,  P. H. Dussault*, and T. K. Trullinger; J. Org. Chem. 200469, 2851-2. 10.1021/jo035191d

53. “Quorum sensing in Candida albicans: probing farnesol-receptor interactions with 40 natural and synthetic farnesol analogs” R. Shchepin, J. M. Hornby,  E. Burger, T. Niessen, P. Dussault, and K. W. Nickerson* Chem. Biol, 2003, 10, 743-750.

52. “Synthesis of (R)- and (S)-10,16-Dihydroxyhexadecanoic Acid:  Cutin Stereochemistry and Fungal Activation”  Aqeel Ahmed ,  S. Cohen-Gould, T. Crawford , Y.S.  Ha, M. Hollrah , F. Noor-E-Ain, M. B. Dickman, and P. H. Dussault* Phytochemistry, 2003, 63, 47-52.

51. “Opening of Substituted Oxetanes with H2O­2 and Alkyl Hydroperoxides:  A Stereoselective Approach to 3-Peroxyalcohols and 1,2,4-Trioxepanes” P.H. Dussault, T. K. Trullinger, and F. Noor-E-Ain, Organic Letters, 2002, 4, 4591-4593. 10.1021/ol0265259

50. “Quorum Sensing in the Dimorphic Fungus Candida albicans is Mediated by Farnesol” J. M. Hornby, E. C. Jensen, A. D. Lisec, J. J. Tasto, B. Jahnke, R. Shoemaker, P. Dussault, and K. W. Nickerson*, Applied and Env. Microbiology 2001, 67, 2982-2992.

49. “Chiral silyl ketene acetals from thioesters:  Reaction with acetals and peroxyacetals to form 3-alkoxy- and 3-peroxyalkanoates” P. H. Dussault, T. K. Trullinger and S. Cho-Shultz Tetrahedron 2000, 9213-9220.

48. "Synthesis of Peroxides through Peroxycarbenium-Mediated C-C Bond Formation:  Scope and Limitations"  P. H. Dussault, R. Lee, H. J. Lee, I. Q. Lee, Q. J. Niu, J. A Schultz and U. R. Zope  J. Org. Chem. 2000, 65, 8407. 10.1021/jo991714z

47. "Lewis acid-mediated reactions of Carbonyl oxides:  A New Take on Ozonolysis" P. H. Dussault and J. R. Raible Org. Lett , 2000, 6478. 10.1021/ol006478p

46. “Reaction of peroxyacetals with silyl ketene acetals:  synthesis of 3-peroxyalkanoates and 3-peroxyalkanals” P. H. Dussault*, R. J. Lee, J. A. Schultz, and Y. S. Suh, Tetrahedron Lett  2000, 41, 5457-60.

45. “Selectivity in  Lewis acid-mediated Fragmentations of Peroxides and Ozonides: Application to the Synthesis of Alkenes, Homoallyl Ethers, and 1,2-Dioxolanes.  P. H. Dussault, H-J. Lee, and X. Liu,. J. Chem. Soc.,Perkins Trans. 1 , 2000, 3006-3013. 

44. “Peroxides as oxidative enzyme inhibitors: Mechanism-based inhibition of a cysteine protease by an amino acid ozonide” P. H. Dussault*, A. D. Georgeb and T. K. Trullinger,  Bioorg. Med. Chem. Lett. 1999, 9, 3255-3258.

43. "Diastereoselective Addition of Singlet Oxygen to Z-Allylic Alcohols:  Effect of Neighboring Functional Groups” P. H. Dussault*, and J. A. Schultz J. Org. Chem., 1999, 64,  8419-22. 10.1021/jo990934+

42. “Lewis Acid-Mediated Displacments of Alkoxydioxolanes:  Synthesis of a 1,2-Dioxolane Natural Product” P. H. Dussault and Xuejun Liu, Organic Lett. , 1999, 1391-3. 10.1021/ol990954y

41. “SnCl4-mediated reaction of ozonides with allyltrimethylsilane: formation of 1,2-dioxolanes” P. H. Dussault and X. Liu, Tetrahedron Lett. 1999, 40, 6553-6.

40. “Photooxygenation of chiral dienol ethers:  asymmetric synthesis of alkoxydioxines” P. H. Dussault,* Q. Han, D. Sloss and D. Symonsbergen.(Tetrahedron, 1999, 55, 11437-54

39.  “Allylmetal-directed addition of 1O2:  Scope, mechanism, and synthetic utility” P. H. Dussault,* C. T. Eary, R. J. Lee and U. R. Zope, J.Chem. Soc., Perkins 1, 1999, 2189-2204.

38. “Total Synthesis of the Alkoxydioxines  (+) and (-) Chondrillin and (+) and (-) Plakorin through Singlet Oxygenation/Radical Rearrangement” P. H. Dussault,* C. T. Eary, K. R. Woller. J. Org. Chem. 1999, 64, 1789-97. 

37. “Metathesis-based Synthesis of Jasmonate and Homojasmonate Lactones, Candidates for Extracellular Quorum Sensing Molecules in Candida albicans”.   S. C. Cho, P. H. Dussault*, A. D. Lisec, E. C. Jensen and K. W. Nickerson*, J. Chem. Soc., Perkins Trans 1. 1999, 193.

36. “Application of the Sonogashira Coupling Reaction Towards the Stereoselective Synthesis of Chiral 1,3-Dienol Ethers”, P. H. Dussault*,  D. G. Sloss, and D. J. Symonsbergen, Synlett  1999 1387.

35. “Hydrogen-Donating Mechamism of Rosmariquinone, an Antioxidant Found in Rosemary” C. A. Hall III, S. L. Cuppett*, and P. Dussault J. Am. Oil. Chem. Soc. 1998, 75, 1147.

34. “Palladium Mediated Carbon-Carbon Bond Forming Reactions as a New Method for the Synthesis of Peroxides and Hydroperoxides” P. H. Dussault and C. T. Eary, J. Am. Chem. Soc. 1998, 120, 7133.

33. “Synthesis and Antioxidant Activity of Rosmariquinone and Several Analogues” Clifford A. Hall III, Susan L. Cuppett*, and Pat Dusssault, J. Agr. Food. Chem. 1998, 46, 1303-1310. 10.1021/jf970742k

32. Singlet Oxygenation/Radical Rearrangement as an Approach to 1,4-Dioxygenated Peroxides:  Asymmetric Total Synthesis of Plakorin and a Revision in the Stereochemical Assignment of Chondrillin"  P. Dussault and K. Woller J. Am. Chem. Soc.1997, 119, 3824-3825.

31. Approaches to the Stereoselective Dioxygenation of Alkenes:  Chiral Phosphite Ozonides" P. H. Dussault and K. R. Woller, J. Org. Chem. 1997, 52, 1556-1559. 10.1021/jo961564h

30. "Auxiliary-Directed Peroxidation of 1,4-Dienes"   P. H. Dussault*,  T. Anderson, M. R. Hayden, K. Koeller and Q. J. Niu,   Tetrahedron  1996, 52, 12381-12398.

29. "Biphasic Singlet Oxygenation with a Perfluoroalkylated Photosensitizer
Steven DiMagno*, P. Dussault*, and J. A. Schultz, J. Am. Chem. Soc. 1996, 118, 5312.

28. "Simple Procedures For Quantification And Reuse Of Common Organic Solvent Mixtures"  P. Dussault* and K. Woller, The Chemical Educator, 1996, 1, 1-6.

27. "Synthesis of 1,2-Dioxanes, 1,2,4-Trioxanes, and 1,2,4-Trioxepanes via Cyclizations of Unsaturated Hydroperoxyacetals"  P. H. Dussault and D. R. Davies  Tetrahedron Lett. 1996, 37, 463-466. 

26. Stereoselectivity of Addition to Chiral Carbonyl Oxides"  P. H. Dussault and U. R. Zope, 1995, J. Org. Chem. 1995, 60, 8218-8222.

25. "The Peroxide Changes Everything"  P. H. Dussault SynLett, 1995, 997-1003 

24. "Synthesis of E,E-Diene Hydroperoxides via  Photoisomerization of Protected Hydroperoxides" P. Dussault* , In Quen Lee, and T. Eary, Lipids , 1995, 30, 591-594 

23. " Reactions of Hydroperoxides and Peroxides"  P. H. Dussault,* in Active Oxygen in Chemistry, C. S. Foote, J. S. Valentine, A. Greenberg, J. F. Liebman, eds.  Blackie Academic and Professional, London, 1995, 141-203. 

22. "Chemoselective Hydrogenation of Unsaturated Peroxides"  P. H. Dussault*, S. E. Kreifels, and I. Q. Lee, Synthetic Communications, 1995, 25, 2613-2621.

21. "Hydroperoxide-Mediated C-C Bond Formation:  Synthesis of 1,2-Dioxolanes from Alkoxyhydroperoxides in the Presence of Lewis Acids P. H. Dussault* and U. R. Zope, Tetrahedron Lett. 1995, 36,  3655-3658.

20. "Reaction  of 1O2 with Alkoxyallylstannanes: Synthesis of 1,2-Dioxolanes and Allyl Hydroperoxides"   P.H. Dussault and U. R. Zope, Tetrahedron Lett., 1995, 36, 2187-2190.

19. "Peroxycarbenium-Mediated C-C Bond Formation:  Synthesis of Cyclic Peroxides from Monoperoxyketals"  P. H. Dussault*, H-J. Lee, and Q. J. Niu  J. Org. Chem. 1995, 60, 784. 10.1021/jo00109a001

18. "A Chemoenzymatic Approach to Hydroperoxyeicosatetraenoic Acids (HPETEs):  Total Synthesis of 5(S)-HPETE"-P. H. Dussault* and I. Q. Lee, J. Org. Chem. 1995, 60, 218-226. 10.1021/jo00106a037

17. "2-(2-methoxyethoxy)-prop-2-yl Hydroperoxide:  A More Easily Handled Reagent for the Synthesis of Hydroperoxides"  P. H. Dussault*, U. R. Zope, and T. A. Westermeyer, J. Org. Chem. 1994, 59, 8267-8268. 10.1021/jo00105a053

16. "Stereoselective Dioxygenation of Enoates"  P. H. Dussault*, K. Woller, M. C. Hillier, Tetrahedron, 1994, 50, 8929-8940.   

15. "Stereospecific Dioxygenation of Allylstannanes:  Synthesis of Enantiomerically Enriched Allyl Hydroperoxides" P.H. Dussault* and R. Lee J. Am. Chem. Soc.  1994, 116, 4485-4486.   

14. "An Organometallic Approach to Peroxyketals"   P. H. Dussault*, A. Sahli, T. Westermeyer,  J. Org. Chem. 1993, 58,  5469-5474.

13. "Peroxycarbenium Mediated Carbon-Carbon Bond Formation:  Synthesis of Peroxides from Monoperoxyketals"  P.H. Dussault*  and I. Q. Lee, J. Am.. Chem. Soc. 1993, 115, 6458-59.     
 
12. "Total Synthesis of 15-HPETE"  P.H. Dussault* and I. Q. Lee, J. Org. Chem. 1992, 57, 1952-1953. 10.1021/jo00033a006

11. "Auxiliary-Directed Dioxygenation:  Stereoselective Synthesis of a Diene Hydroperoxide" P.H. Dussault* and M.R. Hayden, Tetrahedron Letters, 1992, 33, 443-446.  

10. "2-Methoxyprop-2-yl Hydroperoxide:  A Convenient Reagent for the Synthesis of Hydroperoxides and Peracids."  P.H. Dussault* and A. Sahli, J. Org. Chem. 1992, 57, 1009 (Erratum on safety: ibid, 2978 10.1021/jo00036a048)

9. "A New Synthon for Optically Active Diene Hydroperoxides"  P.H. Dussault*, I.Q. Lee, and S. Kreifels,  J. Org. Chem.  1991, 56, 4087-9. 10.1021/jo00013a001

8. "An Olefination-Based Route to Unsaturated Hydroperoxides"  P.H. Dussault* and A. Sahli, Tetrahedron Lett. 1990, 31, 5117-5120.  

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